Utility of Ki-67 (MIB-1) Immunostaining in Cervical Biopsies
نویسنده
چکیده
Nearly every pathologist that practices in a community hospital setting struggles with the accurate and reproducible identification of HPV effect and dysplasia in the female genital tract, and recognizes the fact that in certain situations these conditions can be very difficult to distinguish from reactive changes. Last month in the ProPath "Focus on Immunohistochemistry", we reviewed the potential contributions of immunostaining for p16 (INK4a) in addressing this problem, and this month we focus our attention on the use of Ki-67, a well-known marker of cell proliferation, to assist in these differential diagnostic problems.
منابع مشابه
Evaluation of Ki67, p16 and CK17 Markers in Differentiating Cervical Intraepithelial Neoplasia and Benign Lesions
Background: Cervical intraepithelial neoplasia (CIN) is a premalignant lesion capable of progressing to cervical cancer. Despite the existing well-defined criteria, the histomorphologic diagnosis is subject to high rates of discordance among pathologists. The aim of this study was to evaluate Ki-67 (MIB-1), CK17 and p16 INK4a (p16) markers by immunohistochemical methods in differentiating CIN f...
متن کاملKi-67/MIB-1 immunostaining in a cohort of human gliomas.
Histopathological malignancy grading of human gliomas is limited by subjective interpretation of the morphological criteria. Assessment of mitotic activity is a cornerstone of grading these tumours, but mitotic figures can be hard to identify in haematoxylin-eosin stained sections. Thus, determining proliferative activity by means of Ki-67/MIB-1 immunostaining has become a useful supplement. Ho...
متن کاملUtility of P16/INK4a and Ki-67 in Preneoplasticand Neoplastic Lesions of Cervix
Background and Objective: The currentstudy aimed at investigating the histomorphological spectrum of cervical intraepithelial and invasive lesions assessing the diagnostic significance of P16/INK4a and Ki-67 in such lesions, andcorrelatingP16/INK4a and Ki-67 immunoexpression with histologic type and grade.Methods: A total of 60 cases were selectedcomprisi...
متن کاملUltrarapid Ki-67 immunostaining in frozen section interpretation of gliomas.
BACKGROUND Astrocytic tumours, the most common gliomas, are often classified intraoperatively using standard morphological staining. The final diagnosis and grading of gliomas on paraffin wax sections is often assisted by Ki-67 immunohistochemistry, but standard immunostaining protocols take too long to be used intraoperatively. AIMS To investigate a new rapid Ki-67 immunohistochemical test f...
متن کاملThe relation between bone marrow angiogenesis and the proliferation index Ki-67 in multiple myeloma.
AIM Angiogenesis correlates with disease progression in various haematological malignancies. This study investigated the association between microvascular density (MVD) and the Ki-67 proliferation index (Ki-67 PI), bone marrow infiltration, and C reactive protein (CRP) in patients with multiple myeloma. METHODS Bone marrow MVD was examined in 44 biopsies at diagnosis and 15 in plateau phase b...
متن کامل